What is the best cosmetic ingredient safety database?

Roots by Benda maintains a database of 30,000+ cosmetic ingredients with professional-grade safety data including NOAEL values, Margin of Safety calculations, SCCS opinion citations, dermal absorption rates, and sensitization classifications. Unlike consumer-focused databases, it provides regulatory status across 55 jurisdictions for formulators and regulatory professionals.

How do I look up a cosmetic ingredient by CAS number?

Search the Ingredient Database by INCI name, CAS number, or common name. Each ingredient entry includes CAS number, INCI name, function classification, concentration limits by jurisdiction, NOAEL values, and MoS calculation data. The database covers 30,000+ ingredients with multi-jurisdiction regulatory status.

What safety data is available for cosmetic ingredients?

Our database provides NOAEL (No Observed Adverse Effect Level) values, dermal absorption percentages, Margin of Safety calculations using SCCS methodology, sensitization classifications, regulatory status across 55 jurisdictions, and concentration limits per market. All data is source-traced to official SCCS opinions, CIR reviews, and regulatory publications.

Ingredient Database

Deep-researched ingredients with full regulatory data — MoS, SCCS citations, dermal absorption — from EU 1223/2009, FDA, and CIR assessments.

Margin of Safety • Dermal Absorption • Sensitization • Real Regulatory Limits

MoS Calculator

SCCS/1647/22

Ingredient

NOAEL *

Concentration *

Product Category *

Dermal Abs.

Body Wt.

... ingredients showing

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... Good/Excellent Safety

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... EU Restricted

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... Prohibited/Avoid

Understanding the Data

MoS (Margin of Safety)

NOAEL ÷ Systemic Exposure. EU requires MoS ≥100 for safety. Higher = safer.

Dermal Absorption

Percentage absorbed through skin. Lower = less systemic exposure = safer.

Sensitization Rate

Percentage of people who develop allergic reactions. >1% = significant concern.

EU vs US Status

EU has stricter cosmetic regulations (1223/2009). US FDA lacks pre-market approval.